Ravaged by the effects of the Celestial Collapse and the cessation of power provided by the runes, the eastern lands of Azuma are a shadow of their prosperous past. Weakened by corruptive forces, the gods of nature retreated from the world, leaving mountains to crumble and fields to wither. The people of Azuma seek aid against a blight that has swept these once-bountiful lands. One young hero enters into a contract with a dragon and sets out on a journey in Rune Factory: Guardians of Azuma.
