Combining genetic information with conventional Prostate Specific Antigen, PSA, test results sharpens the precision and the predictive value of conventional PSA tests. Multi-disciplinary researchers at UC-San Francisco and the Stanford Cancer Institute studied 95,768 men and discovered 128 specific genetic associations with prostate cancer. Using this data, they developed a PSA polygenic score that, when combined with conventional PSA levels was 3.4 times more predictive of aggressive prostate cancer than raw PSA values. Such hybrid PSA testing could avoid as many as 31% of negative prostate biopsies for screening purposes and as many 12% of such biopsies for follow up after prostatic cancer therapy.
https://www.nature.com/articles/s41591-023-02277-9
#psa #prostatecancer #genetics #precisiononcology
