Save the Humans uses animated 3-D animals in a UN-style meeting who express concern that AIDS is killing all the humans, which prompts them to launch a Save the Humans campaign.
The four spots highlight different aspects of how HIV/AIDS is a global threat. The cast includes a South African Rhino, a Russian Raven, a British fox and a Burmese Tiger. Their discussions on the global spread of HIV/AIDS lead to a unanimous conclusion that something must be done to 'Save the Humans'.