Series 1 deals with Maddy Smith and Rhydian Morris trying to balance their lives as wolfbloods with their human sides, while trying to keep their secret from being exposed. The start of the show sees Maddy, who lives with her wolfblood family in Stoneybridge, Northumbria, coming ever closer to her first transformation. When new boy Rhydian arrives at Bradlington High School, Maddy recognizes him as being a wolfblood too. Rhydian, who lives with his foster family, has only recently started changing into a wolf, having been unaware of wolfbloods prior to his move to Stoneybridge. The Smith family claim him as a distant cousin, and help him settle in and learn about the wolfblood way of life. Rhydian becomes friends with Maddy's best friends Tom and Shannon, who are unaware of Maddy's and Rhydian's secret. As the series ends Tom and Shannon finally learn the truth.
Series 2 is set three months after the series 1 finale. Jana arrives in Stoneybridge, claiming to have been exiled from the wild wolfblood pack. Despite occasional conflicts with Maddy, she befriends Maddy, Rydian, Tom and Shannon and falls in love with the human world. Eventually she leaves to become the new wild wolfblood pack leader, her father having been exiled. It is discovered that Shannon is spying on the Smiths and collecting information on werewolves. When Maddy is almost killed as a result, she decides to destroy all of the data she has gathered. Liam, a boy at their school, then also begins investigating werewolves. Suspicious of the Smith family, he steals a dog chew from which Dr. Whitewood is able to extract and analyse a sample of the DNA of Maddy's father. With the results proving that the Smiths are not human they are forced to leave the country and, with the help of a contact, go to Canada. At the series' conclusion Maddy says goodbye to her friends and confesses her love for Rhydian.
Series 3 is set two months after Maddy and her family leave Stoneybridge. Rhydian is heartbroken after Maddy's departure. Jana returns from the wild wolfblood pack in dire need of help, bringing with her new allies. Together with his friends, Tom, Shannon and Jana, Rhydian attempts to focus on life beyond school and Stoneybridge. Rhydian meets a new wolfblood named Dacia from a bio-tech company called Segolia, which assists wolfbloods and helped the Smiths to leave the country. She tells him that Maddy and her parents are safe in Canada, and offers him a job with the company which is secretly run by wolfbloods and their human allies. It transpires that Segolia is researching the medical uses of wolfblood DNA. They are particularly interested in Jana and her wild pack because they have special abilities, verging on telepathy or magic, that are lost to other wolfbloods. Dr. Whitewood reappears, still desperate to find evidence of wolfbloods, but Dacia prevents her from revealing the wolfblood secret by bribing her with the offer of a job at Segolia. As the series accelerates towards a climax, Rhydian must unite the wild wolfblood pack or their species will face extinction. The series ends with Rhydian reuniting with Maddy (both in wolf form) in the snow in Canada.
Series 4 begins with a plea for help from wolfblood brother and sister Matei and Emilia, and becomes the catalyst for the formation of a new pack. With the wolfblood secret looking increasingly fragile the pressures on Jana grow, forcing her to question where she truly belongs and who she can trust. This leads to a cataclysmic decision that will change all of their lives forever.
Series 5 begins with the secret no longer a secret, and the world has changed for Jana, Matei, Selina, TJ and Imara. Suddenly they’re the most visible wolfbloods on the planet, and everyone has an opinion about what they did. Some humans are excited by the reveal of this new species – and some are hostile and scared. As tensions rise on both sides, difficult choices lie ahead.
