Spider-Man finds himself beset by his enemies from the movies: Green Goblin, Doctor Octopus, Sandman, and Venom. He gains help from New Goblin as he combats the villains. All six characters suddenly find themselves targeted by an enemy force and one-by-one, the villains begin disappearing. Meanwhile, Spider-Man is rescued by Nick Fury of S.H.I.E.L.D., who informs him that the meteor which brought the Venom symbiote to Earth had broken up in the Earths atmosphere and five more pieces had landed in numerous locations across the globe.