Danny Care and Mako Vunipola will start for England as they attempt to secure their first Grand Slam title since 2003 by beating France in Paris on Saturday.
Scrum-half Care and loose-head prop Vunipola replace Ben Youngs and Joe Marler respectively.
Youngs and Marler are on the bench as England make two changes to the XV that started in the 25-21 win over Wales.
England head coach Eddie Jones said: "We've picked our best 23 who we know can get the job done in Paris."
Marler drops to the replacements despite being cleared to play at the Stade de France late on Wednesday evening following a disciplinary hearing.
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