Upin and Ipin are five-year-old Malay twins who live with their elder sister Ros and maternal grandmother Uda (whom they call Opah) in a wooden house in Kampung Durian Runtuh. They have lost their parents in their infancy. Upin and Ipin study in the villages Tadika Mesra (Friendly Kindergarten), where they befriend a motley bunch of classmates, including the adorable and right-thinking Mei Mei, a jocular and poetic Jarjit Singh, the firm but clumsy and short-tempered Ehsan, an easygoing and sarcastic Fizi (Ehsans cousin), and an entrepreneurial and meticulous Mail.\r
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The headman of Kampung Durian Runtuh is Isnin bin Khamis, better known as Tok Dalang, the wayang kulit champion. Tok Dalang keeps a cluster of rambutan trees for commercial purposes, and a rooster named Rembo. Among the villages other notable residents are Muthu, owner of the villages only food stall who lives with his animal whisperer son Rajoo and pet steer Sapy; Salleh (Sally), a waspish transgender-apparent, who owns a mobile library; and Ah Tong, a strident-voiced vegetable farmer. Kampung Durian Runtuh also invited an Indonesian girl named Susanti who moved in with her family.