According to Laqueur, prior to the eighteenth century it was acknowledged that there were physical differences between the sex organs of men and women, but these differences were never made to be of significance; "no one was much interested in looking for evidence of two distinct sexes, at the anatomical and concrete physiological differences between men and women, until such differences became politically important."[3] Until the beginning of the eighteenth century, Laqueur claims, the one sex model dominated medical and philosophical literature and there was a web of knowledge to support it.