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Full-back Luke Shaw suffered a double fracture of his right leg in Manchester Uniteds 2-1 Champions League loss at PSV Eindhoven.
Shaw, 20, will have an operation on his return to Manchester, the club said.
He received oxygen while being treated on the pitch for 10 minutes after Hector Morenos tackle.
It is awful. It was a very bad tackle. He had the oxygen mask on and was crying in the dressing room, said manager Louis van Gaal.
Mexico defender Moreno sent his strength to the left-back and wished him a fast recovery.
The 27-year-old, who broke his leg during last years World Cup, added: Ive been through this before and I know how it feels.
Shaw moved to Old Trafford from Southampton in June last year in a £31m deal and made 20 appearances in an injury-interrupted first season.
He has started all of Uniteds eight games this season, as well as playing in Englands European Championship qualifiers against San Marino and Switzerland.
Yet with just nine months to go until Euro 2016, Shaw has suffered a broken tibia and fibula.
