At the age of 10, Galante was sent to reform school due to his criminal activities. He soon formed a juvenile street gang on New York's Lower East Side. By the age of 15, Galante had dropped out of seventh grade. As a teenager, Galante became a Mafia associate during the Prohibition era, becoming a leading enforcer by the end of the decade. During this period, Galante also worked as a fish sorter and at an artificial flower shop.
