Von Graefe's sign (lid lag sign) is the immobility or lagging of the upper eyelid on downward rotation of the eye, indicating exophthalmic goiter (Graves' Disease).[1]
A pseudo Graefe's sign (pseudo lid lag) shows a similar lag, but is due to aberrant regeneration of fibres of the oculomotor nerve (III) into the elevator of the upper lid.[2] It occurs in paramyotonia congenita.[3] A pseudo Graefe's sign is most commonly manifested in just one eye but can occasionally be observed in both. The reason why only one eye is affected is not yet clear.
