A regenerated kidney, which was grown in a laboratory has been transplanted into a living animal and has successfully produced urine, scientists at Massachusetts General Hospital in Boston announced on Sunday.
The scientists started with the kidneys of recently deceased rats and used detergent to wash away the old cells leaving behind an underlying scaffold of connective tissues. They then regenerated the organ by seeding the scaffold with human umbilical-vein cells to line the blood vessels, and kidney cells from newborn rats to produce other tissues that make up the organ. The seeded scaffold was then put into an organ bioreactor to grow until it is ready for transplantation. However once transplanted into rats, the regenerated kidney was only able to produce one third as much as urine as normal kidneys, and cleared creatinine 36 times slower than normal.
This method was developed by organ-regeneration specialist Harald Ott in 2008. Ott has used the technique to grow hearts and lungs since then. The team is now testing the same technique using pig and human kidneys.
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