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Avian influenza vaccines have been used for more than 10 years in China. More than 10 years ago, some poultry raising farms in China used the H5N1 avian influenza vaccine. They were not forced but voluntary to use vaccines. Between 2001 and 2005, when China avian influenza vaccine industry just started, various problems frequently emerged. To resolve these problems, Ministry of Agriculture of China set up an entry barrier of the avian influenza vaccine producing market and tightly supervised it. It established strict regulations on the production and sales of avian influenza vaccines. For example, avian influenza vaccines must be produced in workshops that are in compliance with GMP and must be inspected every year.